Director, Skin & BioSubstrates

 

Dr. Gourion-Arsiquaud is the molecular and structural analysis expert at TRI. He uses various spectroscopic and microscopic techniques for the characterization of biomaterials and the study of biological modifications associated with specific conditions like treatment, drug use, disease, age or environmental factors.
 
Dr. Gourion-Arsiquaud’s expertise lies in multiple biophysical techniques with a special emphasis on vibrational spectroscopies (FTIR & Raman) for bio-material sciences. He has more than 10 years of research experience, including technique development, project design and coordination, as well as a successful track record of achievements. Over the years, Dr. Gourion-Arsiquaud extended the application of its biophysical techniques, to diverse biological tissues; Bone, teeth, nail, hair and skin.
 
Dr. Gourion-Arsiquaud received a doctorate in Biochemistry with a specialization in Biophysics from the University of the Mediterranean (France) in 2005. He began his career at the Hospital for Special Surgery (HSS)/Weill Cornell Medical College studying the mechanisms of biomineralization via analyses of the mineral and matrix properties in mineralized tissue (bone, teeth). Aftre as associate researcher, Dr. Gourion-Arsiquaud has been examining the structural and functional analysis of Lipid/Protein interactions involved in the host - defense mechanism at Rutgers University.

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Since he joined TRI in 2011 Dr. Gourion-Arsiquaud developed innovative tests, research areas and product evaluations relevant to cosmetic sciences, material analysis and medical applications; from technology development to product design and performance evaluation on hair, nail and skin care products. He also developed several long-standing external collaboration with academic leaders at local universities (Cornell, HSS, Rutgers, Columbia, University of Pittsburg).

 

Dr. Gourion-Arsiquaud was promoted to Director Skin & BioSubstrates in May 2017 to reflect his developing stature as leader of this important growing Cosmetic Business within TRI.
 
Recent Publications

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Samuel Gourion-Arsiquaud, Ph.D.
Principal Research Scientist
Gamsjaeger S, Mendelsohn R, Boskey AL, Gourion-Arsiquaud S, Klaushofer K, Paschalis EP. Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry. Curr Osteoporos Rep. 2014 Dec;12(4):454-64.
 
Gourion-Arsiquaud S, Marcott C, Hu Q, Boskey AL. Studying variations in bone composition at nano-scale resolution: a preliminary report. Calcif Tissue Int. 2014 Nov:95(5):413-8.
 
Gourion-Arsiquaud S, Lukashova L, Power J, Loveridge N, Reeve J, Boskey AL. Fourier transform infrared imaging of femoral neck bone: reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls. J Bone Miner Res. 2013 Jan;28(1):150-61. Selected for F1000Prime.
 
Westerterp M*, Gourion-Arsiquaud S*, Murphy AJ*, Shih A, Cremers S, Levine RL, Tall AR, Yvan-Charvet L. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012 Aug 3;11(2):195-206. * These authors contributed equally to this work.
 
Burket J, Gourion-Arsiquaud S, Havill LM, Baker SP, Boskey AL, van der Meulen MC. Microstructure and nanomechanical properties in osteons relate to tissue and animal age. J Biomech. 2011 Jan 11;44(2):277-84.
 
Gourion-Arsiquaud S, Allen MR, Burr DB, Vashishth D, Tang SY, Boskey AL. Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity. Bone 2010 Mar;46(3):666-72.
 
S. Gourion-Arsiquaud, J.C. Burket, L.M. Havill, E. DiCarlo, S.B. Doty, R. Mendelsohn, M.C.H.  van der Meulen, and A.L. Boskey. Spatial variation in osteonal bone properties relative to tissue and animal age. J Bone Miner Res 2009 Jul;24(7):1271-81..
 
Gourion-Arsiquaud S, Faibish D, Myers E, Spevak L, Compston J, Hodsman A, Shane E, Recker RR, Boskey ER, Boskey AL. Use of FTIR Spectroscopic Imaging to Identify Parameters Associated with Fragility Fracture. J Bone Miner Res 2009 Sep;24(9):1565-71.
 
Gourion-arsiquaud Samuel, Boskey Adele. L. Fourier transform infrared and Raman microspectroscopy and microscopic imaging of bone. Current Opinion in Orthopaedics 2007 Sept 18 (5): 499-504.
 
Vidaud C, Gourion-Arsiquaud S, Rollin-Genetet F, Torne-Celer C, Plantevin S, Pible O, Berthomieu C, Quemeneur E. Structural Consequences of Binding of UO(2)(2+) to Apotransferrin: Can This Protein Account for Entry of Uranium into Human Cells? Biochemistry 2007 Feb 1.
 
Samuel Gourion-Arsiquaud, Soizic Chevance, Lionel Garnier, Arnaud Bondon, Catherine Berthomieu. Identification of a Cd2+ and Zn2+ binding site in cytochrome c using FTIR coupled to an ATR micro-dialysis set-up and NMR spectroscopy. Biochemistry 2005 Jun 21; 44(24):8652-63.
 
Rainer Hiernerwadel, Samuel Gourion-Arsiquaud, Roberto Bassi, Bruce Diner, Catherine Berthomieu. Formate binding near the redox-active TyrosineD in Photosystem II: consequences on the properties of TyrD. Photosynth Res 2005 Jun; 84(1-3):139-44.
 
Book Chapter
 
Samuel Gourion-Arsiquaud, Joel Coret, David J. Moore. Chapter "Fourier Transform Infrared (FTIR) Spectroscopic Imaging Analysis of Topical Formulations". Apply Topically: a practical guide to formulating topical applications 2014. (Nava Dayan).
 
Samuel Gourion-Arsiquaud, Paul A. West and Adele L. Boskey. Chapter "Fourier Transform Infrared (FT-IR) Microspectroscopy and Microscopic Imaging". Osteoporosis, Methods and protocols 2008. (Westendorf, Jennifer J. Ed.)